| viXra.org > Physics of Biology > 2412 |
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| viXra.org > Physics of Biology > 2412 |
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[5] viXra:2412.0190 [pdf] submitted on 2024-12-31 15:47:15
Authors: Daoudi Rédoane
Comments: 9 Pages.
Microtubules are essential components of the cytoskeleton in eukaryotic cells, playing pivotal roles in intracellular transport, cell division, and maintaining cell structure. Their dynamic behavior, such as polymerization, depolymerization, and their response to variouscellular signals, makes them a fascinating subject for study. While biochemical and biophysical research has significantly advanced our understanding of microtubule function, recent mathematical models have provided new insights into their dynamics, stability, and interactions with other cellular components. This article explores the application of advanced mathematical tools to model the structure, dynamics, and functionality of microtubules. Techniques such as differentialequations, statistical mechanics, network theory, and computational simulations are employed to describe microtubule behavior at multiple scales, ranging from individual tubulin dimers to entire microtubule assemblies. We highlight key models that have advanced the understanding of microtubule dynamics and discuss how these models canbe applied to uncover the molecular mechanisms underlying various cellular processes and diseases.
Category: Physics of Biology
[4] viXra:2412.0179 [pdf] submitted on 2024-12-27 23:06:26
Authors: Daoudi Rédoane
Comments: 7 Pages.
Ion channels are essential for the proper functioning of excitable cells, governing key processes such as action potentials, resting membrane potential and cellular homeostasis. The kinetics of ion channel opening, closing, andinactivation are critical to their proper function, and mathematical modeling of these processes offers valuable insights into both normal physiology and pathophysiological conditions. This article explores the biomathematics behind ion channel kinetics, focusing on the mechanisms of channel gating andinactivation, and how these processes are mathematically described. Furthermore, it discusses the implications of ion channel dysfunction in various diseases, including neurological disorders, cardiac arrhythmias, muscular diseases, and cystic fibrosis. By modeling the dynamics of ion channel statesand incorporating experimental data, mathematical approaches help to elucidate disease mechanisms and support the development of targeted therapies for ion channel-related diseases. This work highlights the power of biomathematical models in advancing our understanding of cellular physiology andin guiding clinical interventions.
Category: Physics of Biology
[3] viXra:2412.0171 [pdf] submitted on 2024-12-28 23:17:46
Authors: Daoudi Rédoane
Comments: 6 Pages.
The process of messenger RNA (mRNA) translation is a fundamental biological mechanism through which genetic information is converted into functional proteins. This article explores the mathematical principles used to model mRNA translation,the components of these models, and their applications in understanding cellular biology and disease.
Category: Physics of Biology
[2] viXra:2412.0157 [pdf] submitted on 2024-12-24 13:24:20
Authors: Daoudi Rédoane
Comments: 5 Pages.
Proteins are the molecular machines that drive almost every biological process in living organisms. The correct folding of a protein is crucial for its function, as its three-dimensional structure determines its biochemical properties and interactions with other molecules. However, protein folding is not always perfect. Misfolding or incomplete folding can lead to dysfunctional proteins, which is implicated in various diseases. One of the most significant classes of diseases caused by protein misfolding are textit{channelopathies}, disorders that involve ion channel dysfunction, often due to the misfolding of ion channel proteins.This article delves into the kinetics of protein folding, explores the mathematical models that describe the folding process, and investigates how anomalies in folding kinetics contribute to the pathophysiology of channelopathies. The article covers the physical principles behind protein folding, the influence of mutations on folding dynamics, and how disruptions in folding kinetics lead to misfolded ion channel proteins, causing diseases such as cystic fibrosis, epilepsy, and certain cardiac arrhythmias.
Category: Physics of Biology
[1] viXra:2412.0051 [pdf] submitted on 2024-12-09 21:18:48
Authors: Alexis Zaganidis
Comments: 17 Pages.
1) The "great" statistical anomaly of "natural" radioactive radiation. The "natural" radioactive radiation can be separated into two "independent" sources : cosmic one and terrestrial one or non-cosmic one. In order to have an over-optimized human intelligence, the sum of these two "independent" sources has been greatly minimized thanks to the fine tuning of physical constants, thanks to a very particular cosmic formation called the KBC Void and thanks to a very particular planetary formation in the case of the Earth itself. 2) The atomic tests on tropical islands between 1946-1967 (previously evacuated of all human life) have heavily irradiated these tropical islands and have therefore boosted the fungal diseases of tropical living organisms. The mosquito is one of the most mobile & dynamic tropical living organisms and therefore the most sensitive & susceptible to fungal diseases which greatly reinforce the supremacy of static life. Therefore, the atomic tests on tropical islands have had a very positive effect against malaria and all tropical diseases transmitted by mosquitoes.
Category: Physics of Biology
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