Physics of Biology

Showing Role of Angiotensin-converting Enzyme 2 in Covid-19 Using Novel Fic-Fac Ratio

Authors: John Yuk Ching Ting
Comments: 14 Pages. Case Report of 43 year-old man with severe ARDS from pneumonia together with applications from Fic-Fac Ratio to creatively explain COVID-19’s drug and vaccine developments, and mitigation measures to combat the resulting pandemic.

Objectives: We utilize a Case Report of severe acute respiratory distress syndrome (ARDS) from pneumonia together with applications from Fic-Fac Ratio to creatively explain COVID-19's drug and vaccine developments, and mitigation measures to combat the resulting pandemic (declared by World Health Organization on March 11, 2020). Methods: Diagnostic test 'Accuracy' refers to ability of that test to distinguish between patients with disease, and those without. Our novel Fic-Fac Ratio, which is an acronym that stands for Fictitious-Factitious Ratio, is roughly considered as 'Inverse Accuracy' with higher Accuracy corresponding to lower Fic-Fac Ratio and vice versa. Regarded as tertiary spin-off from mathematically proving open problems in Number theory of Riemann hypothesis (and explaining two types of Gram points), Polignac's and Twin prime conjectures; we succinctly outline the derivation of this Ratio. Results: 2003 Case Report of 43 year-old male presenting with severe ARDS due to Bilateral Early Lobar Pneumonia of uncertain viral etiology resulting in death at a small Australian regional hospital. ACE is an acronym that stands for angiotensin-converting enzyme. The functions of ACE and its counterpart ACE2 are outlined. Physiological and pharmacological implications of ACE2 also acting as entry receptor for the coronavirus causing COVID-19 infection are detailed. Epidemiological principles on modelling COVID-19 pandemic with 'less accurate' SIR model versus 'more accurate' SEIR model are also presented. Conclusions: Controlling COVID-19 pandemic and developing effective COVID-19 drugs and vaccine(s) can be creatively explained using Fic-Fac Ratio. International collaboration is generally required to defeat COVID-19.
Category: Physics of Biology