Quantitative Biology

2510 Submissions

[3] viXra:2510.0143 [pdf] submitted on 2025-10-28 20:40:15

An Accurate Bell Curve Discovered in Intraspecific Body Mass Distribution of 1k Beetles

Authors: Nagi Nangirky Ogata, Norichika Ogata
Comments: 4 Pages. 1 figure, 10 references

While the normal distribution is often termed "normal," it is uncommon to encounter precise bell curves in biological measurements. In this study, we discovered an accurate normal distribution in the intraspecific body mass distribution of the Scarab Beetle Anomala albopilosa. We captured over thousands of beetles and measured their weight, and we also conducted a Mark-Release-Recapture study.
Category: Quantitative Biology

[2] viXra:2510.0115 [pdf] submitted on 2025-10-24 21:28:23

Synergistic and Antagonistic Effects of Drug Combinations on Tumor Cell Migration in a Fibroblast Scratch Assay Model

Authors: Daniel Suh, Akhil Patel, Sriyan Daggubati
Comments: 5 Pages.

This study examined the effects of 12 biochemical agents, including chemotherapies, a dilution series of Etoposide, copper (II) ions, and other bioactive compounds, on tumor cell migration using a fibroblast scratch assay. Agents were applied to adult mouse fibroblasts, and migration was quantified via microscopy and cell counts. Chemotherapies such as 5-Fluorouracil, Cytarabine, Etoposide, and Cycloheximide showed varied effects based on mechanisms like DNA synthesis inhibition and apoptosis induction. Copper (II) ions and Vanadate promoted mitochondrial damage and tumor suppressor activation, while Retinoic Acid inhibited proliferation and metastasis-related signaling. Resveratrol demonstrated the strongest inhibition of cell migration, with logistic growth modeling suggesting lasting effects on tumor proliferation. These results highlight how Resveratrol can act as a dual-action therapeutic and support further investigation into its use in cancer treatment.
Category: Quantitative Biology

[1] viXra:2510.0081 [pdf] replaced on 2026-05-03 15:26:28

An Integrative Bioinformatics Framework for Transcriptomic Reanalysis Reveals Regulatory Architectures in the Lychee Response to Peronophythora

Authors: Eric Zhuang
Comments: 26 Pages.

Lychee (Litchi chinensis Sonn.) is an economically important tropical fruit threatened by litchi downy blight, caused by the oomycete Peronophythora litchii. To prioritize genes and regulatory features associated with early host responses, we reanalyzed public leaf RNA-seq data from Guiwei and Yurong cultivars (GSE201243; mock and inoculated samples, three biological replicates per group). Differential-expression analysis identified 17 significant DEGs in Guiwei and 117 in Yurong at adjusted P < 0.05, suggesting a broader transcriptional response in Yurong. Eighteen highly responsive genes were selected for structural, motif, promoter, and candidate interaction analyses. These candidates included annotations associated with defense or stress responses, including jacalin-like lectin, pathogenesis-related protein, heat-shock protein, thaumatin/osmotin-like proteins, cytochrome P450, lipid-transfer proteins, and calcium-binding proteins. A selected-gene interaction contrast prioritized LITCHI019519, LITCHI001510, LITCHI028401, LITCHI017676, LITCHI028104, and LITCHI019183 as potential cultivar-dependent response genes. Promoter analysis of 2-kb upstream regions detected stress- and hormone-associated cis-elements, and a random-promoter background test supported enrichment of ARE, MeJA-responsive motifs, TCA-elements, and TC-rich repeats. These results provide testable candidates for future functional validation of lychee resistance to P. litchii.
Category: Quantitative Biology